How does the immune-system influence our mood? Why are people with inflammatory conditions or neurodegenerative diseases much more prone to develop depression? These are some of the questions we are trying to answer in the CAN-group, in the hope to uncover better treatments and tools for early diagnosis of affective disorders and neurodegenerative disease.
Our research evolves around deciphering the neural circuits and immune-to-brain signalling mechanisms involved in regulating affective state during disease. For this we are exploring the function of several brain circuits and neural populations (such as microglia); and are specialized in striato-nigral and mesolimbic connectivity. We are particularly focused on exploring the mechanisms underlying major depressive disorder and Parkinson's Disease, using state-of-the-art neurocircuitry techniques.
Our lab is technically specialized in: in vivo neurocircuitry techniques such as Designer Receptors Exclusively Activated by Designer Drugs (DREADDS) and Optogenetics in combination with various affective, motivational and motoric behaviours; Viral tracing strategies; methods for identifying active neuronal ensembles during specific behaviors; fluorescent immunohistochemistry and confocal microscopy.
We are a young and dynamic team that works hard to find new ways for improving the diagnosis and treatment of affective diseases - We believe we CAN solve the problems of affective neuroscience
Dr. Anna M. Klawonn,
Research leader
The CAN-group is a part of the Department of Drug Design and Pharmacology at University of Copenhagen, Denmark
For further information please visit the University of Copenhagen Web-page
Skytt D*, Klawonn AM*, Stridh MH, Pajecka K, Patruss Y, Quintana-Cabrera R, Bolanos JP, Schousboe A, Waagepetersen HS.
siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate. 2012. Neurochemistry International. *These authors contributed equally to the manuscrip
Assistant professor and PI for the CAN-group, at University of Copenhagen
Postdoc with professor Robert C. Malenka, Stanford University, USA
PhD in Medical Science, Linköping University, Sweden
BSc in Biochemistry and Molecular Biology, University of Southern Denmark
Interest: Neurocircuits of motivation and affective state, Immune-to-Brain Signalling, Gut-to-Brain Axis, Major Depressive Disorder, Treatment Resistant Depression, Parkinson's Disease
PhD in Neurocience, Karolinska Institutet
MSc in Neuroscience, University of Crete
BSc in Biology, University of Crete
Interests:
MSc in Pharmaceutical Science, University of Copenhagen, Denmark
Interests: Parkinson's disease, Affective state, Microglia, Dopamine, DREADDs, mouse behavior
MSc in Pharmaceutical Science, University of Copenhagen, Denmark
Interests: neurocircuits of affective state, Parkinson's disease, depression, immune-to-brain signalling, mouse behavioral assays, finding potential targets for new treatments for depression and motor disturbance
Neuroscience Academy Denmark student, University of Copenhagen, Denmark
Interests: astrocyte-neuron communication, cAMP, plasticity, neurocircuits of affective state, in vivo 2-photon imaging, behavioral neuroscience
BSc in Biochemistry, University of Granada, Spain
Interests: Microglia, Fluorescent Immunohistochemistry, Confocal microscopy
BA of arts, Neuroscience, University of Colorado Boulder
BA of arts, Psychology, University of Colorado Boulder
Interests: finding new treatments for treatment resistant depression and anxiety, 5-HT signalling, psychoplastogenic compounds - psychedelics, optogenetics and DREADDs, affective behaviors
Bachelor of Pharmacy, Manipal Academy of Higher Education
Interests: Affective states, depression and anxiety, Optogenetics, and Mouse behavioural assays
BSc in Biotechnology, University of Pavia
Interests: Dopamine transmission, affective states and depression
University of Copenhagen
Interests: transgenic mouselines, genotyping, behavior, primary neural cell cultures
University of Copenhagen - https://ilf.ku.dk/ansatte/?pure=da/persons/321896
Interests: Receptor Pharmacology (5-HT)
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